Intravascular large B-cell lymphoma diagnosed at autopsy

Background: Intravascular large B-cell lymphoma is a rare, extranodal characterised by intravascular growth of malignant mature population, primarily affecting capillaries. Pre-mortem diagnosis can be challenging as patients often present with non-specific clinical findings including fever unknown origin, decreased general condition and neurological abnormalities. Radiological may or falsely negative. Aims: We the case an 87-year-old lady who presented to hospital cognitive functional decline, headache presumed transient ischaemic attacks. Despite extensive investigations definitive cause for her symptoms was unable established prior death. Autopsy revealed multiorgan involvement lymphoma. Methods: The patient underwent full non-coronial autopsy. With consent, patient’s brain retained extended fixation neuropathological assessment which also widespread lymphomatous infiltration. Results conclusions: This demonstrates rare diagnosed at autopsy highlights difficulties in pre-mortem due presentation lack diagnostic radiological features.